1-bromo-8-chloronaphthalene

IUPAC Name: 1-bromo-8-chloronaphthalene

Synonyms: Naphthalene, 1-bromo-8-chloro-

Catalog NO.:
CAS NO.: 20816-79-9
Brand: Daisa Biopharma
Category: Intermediate, Naphthalene
Tag: 4-1-Bromo-8-chloronaphthalene, Adgrasib intermediate

Molecular Formula: C10H6BrCl

Molecular Weight: 241.51
Pack Size Available: 25 g, 100 g, 1.0 kg
Place of Origin: India

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cGMP Capacity

kg to MT scale
GMP batches production
Over 20 years of experience

HPAPI production with OEL < 1 μg/m³
Cleanroom Class 100 to Class 100,000
Special type of reactions in cGMP workshop

Cleaning level: Class A B C
cGMP synthesis workshop

Product Description

Due to its polycyclic aromatic structure, the compound exhibits typical aromatic stability and is poorly soluble in water but readily dissolves in common organic solvents such as ethanol and diethyl ether. The presence of bromine and chlorine atoms enhances its chemical reactivity, making it a useful intermediate in organic synthesis, particularly in the preparation of pharmaceuticals and agrochemical compounds.

The molecule undergoes electrophilic aromatic substitution reactions, and its halogen substituents can also act as leaving groups in various nucleophilic substitution or cross-coupling reactions. As with many halogenated aromatic compounds, appropriate safety measures should be followed during handling, as exposure may be harmful through inhalation or ingestion.

Uses: 1) Used to synthesize inhibitors for KRas G12C and G12D mutations, crucial in cancer treatment.
2) Important in materials science and organic electronics.

Appearance: White to Brown powder to crystal

HPLC purity: ≥98% a/a

NMR: Confirm the structure

Physical Form: Solid

Melting Point: 87-88 oC

Shipping Temperature: Keep the container tightly closed in a dry, well-ventilated area. Containers that are opened must be carefully resealed and kept upright to prevent leakage. Inert atmosphere, Room Temperature

Storage Temperature: Keep container tightly closed in a dry and well-ventilated area. Containers that are opened must be carefully resealed and kept upright to prevent leakage. Inert atmosphere, Room Temperature (Recommended in a cool and dark place, <15°C)

Inchi Code: 1S/C10H6BrCl/c11-8-5-1-3-7-4-2-6-9(12)10(7)8/h1-6H

Inchi Key: JHZQEADUKRNQBX-UHFFFAOYSA-N

SMILES: ClC1=CC=CC2=CC=CC(Br)=C12     

20331999

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